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Please find all the frequently asked questions regarding our product Animate. If you cannot find the answer to your questions or if you are interested to know more about this product, please do not hesitate to contact us.


What is clinical Milk fever? What is subclinical hypocalcemia?

Hypocalcemia is a disorder in dairy cows caused by lower than normal blood calcium concentrations. There are two forms of the disorder, clinical and subclinical. Clinical hypocalcemia, more commonly referred to as clinical milk fever (MF), is defined as a cow having a total blood calcium concentration below 5.5 mg/dl and showing physical signs of the disorder (muscle tremors, drop in body temperature, laterally recumbent). Subclinical hypocalcemia (SCH) is defined by a total blood calcium concentration ranging from 5.6 to 8.5 mg/dl and showing no physical signs of the disorder.

Why worry about subclinical hypocalcemia (SCH)?

Cows affected by subclinical hypocalcemia (SCH) are less productive and less profitable, with an estimated cost to dairymen of approximately €112.00 per case. Since more cows are affected by SCH (> 50%) than MF (typically, < 5%), SCH has a larger negative impact on dairy profitability.
(Oetzel, G.R. 2012. An update on hypocalcemia on dairy farms. Proceedings of Four-State Dairy Nutrition & Mgmt. Conf.)

How do I determine the incidence of subclinical hypocalcemia (SCH) in my herd?

The prevalence of subclinical hypocalcemia (SCH) in a herd can be determined by measuring blood calcium concentrations between 48 and 72 hours following calving. Before doing so, it is necessary to establish a threshold level of blood calcium concentration that is considered “normal”. It is generally accepted that a value above 8.5 mg/dl is normal.

Negative Dietary Cation-Anion Difference (DCAD) Diets

What does Dietary Cationic-Anionic Difference (DCAD) mean?

DCAD stands for “Dietary Cation-Anion Difference”. It is a measure of the milliequivalent difference between positively charged minerals, or cations (predominantly potassium and sodium), in relation to the negatively charged minerals, or anions (predominantly chloride and sulfur), in a ration. DCAD is calculated using the molecular weight and charge of these four minerals.

Why feed a negative dietary cation-anion difference (DCAD) diet?

Regardless of age, all prepartum dairy cows are susceptible to hypocalcemia due to the rapid increase in calcium requirements around calving. Cows that are hypocalcemic have increased odds of developing retained placenta, metritis, mastitis and displaced abomasum which can lead to reduced milk yields and decreased fertility. Feeding a negative DCAD diet to cows prior to calving helps reduce the risk of developing hypocalcemia.

How do negative dietary cation-anion difference (DCAD) diets work to reduce hypocalcemia?

Negative DCAD diets work by causing a moderate, compensated metabolic acidosis and aciduria. This is accomplished by feeding elevated levels of anionic minerals containing chloride and/or sulfur. The compensated metabolic acidosis lowers blood pH and, through the actions of parathyroid hormone and vitamin D, enhances the cows’ natural physiological mechanisms for maintaining normal blood calcium concentrations. These include dietary calcium uptake by the gut and bone release of stored calcium. Aciduria induces urinary excretion of calcium prepartum therefore increasing the flux of calcium through the exchangeable calcium pool.

Can cows be harmed with a too negative dietary cation-anion difference (DCAD) diet?

No. When cows are fed diets that are over-acidified (this varies by farm) they will adjust dry matter intake downward to prevent over-acidification.

With the feeding of a negative DCAD diet are there any risks associated from removing too much calcium from bone, thereby, causing weak bones?

No. It is estimated that the amount of calcium stored in bone in the adult dairy cow ranges between 7.8 to 8.5 kilograms. During the late gestation and early lactation periods a dairy cow will support the requirement for milk calcium in two ways. First, by increasing the amount of calcium absorbed from the diet and secondly, by releasing calcium from bone, a process known as lactational osteoporosis. These combined processes typically occurs over a 6 to 8 week period during early lactation at which point the cow returns to a positive calcium balance (Hibbs and Conrad, 1983). The significantly shorter period of time that a cow may be fed an acidogenic diet (21 to 28 days) does not pose a threat to depletion of bone calcium.

Will a negative DCAD diet resulting in a urine pH of 7.5 produce any positive results with respect to reducing hypocalcemia?

No. For negative dietary cation-anion difference (DCAD) diets to work you must feed enough anions to lower urine pH significantly below a urine pH of 7.5. Most researchers agree that a diet resulting in a urine pH below 6.8 must occur to have any positive effect. However, diets that induce a moderate compensated metabolic acidosis and aciduria, resulting in urine pH values from 5.5 to 6.0 work best.



Animate helps to optimise calcium metabolism around calving which may result in healthier, more productive dairy cows.

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Why Feed Animate?

What is Animate?

Animate anionic mineral complementary feed is manufactured with proprietary technology that results in a product that is highly concentrated and highly palatable.

What makes Animate different from other anionic products/salts?

The unique proprietary manufacturing process used to make Animate, incorporates mineral salts into a carrier matrix, making Animate highly concentrated and palatable.

What effect on health events can I expect after feeding a properly formulated negative dietary cation-anion difference (DCAD) ration?

Calcium is a critical mineral involved in many biological functions including muscle contractions, nerve conduction and immune cell function. Feeding a properly balanced negative dietary cation-anion difference (DCAD) diet can result in reductions in clinical and subclinical hypocalcemia, displaced abomasum, retained placenta and metritis.

What is the difference between feeding Animate and magnesium chloride or calcium chloride?

Animate is a mixture of several mineral salts manufactured with a proprietary process resulting in enhanced palatability. In addition, Animate supplies both chloride and sulfur. Feeding a combination of chloride and sulfur leads to better dietary cation-anion difference (DCAD) diet results. Magnesium chloride and calcium chloride are single source mineral salts that can be unpalatable and do not supply any sulfur. Maintaining high dry matter intake during the close-up period has positive benefits to the cow both prior to and following calving. Choosing an anionic mineral product that is palatable helps to achieve high dry matter intakes during the close-up period.

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How much Animate do I need to feed?

The amount of Animate to feed will vary between farms but will always be the amount needed to result in a urine pH range from 5.5 to 6.0. This is typically from 0.70 to 0.80 kg per day.

How do I determine if I am feeding the proper dietary cation-anion difference (DCAD) level?

Learning if the proper dietary cation-anion difference (DCAD) level is being fed can be determined by measuring urine pH. Properly formulated and fed negative DCAD diets result in urine pH values from 5.5 to 6.0. The best time to monitor urine pH values is 6 to 9 hours after the delivery of feed.

Why do I have to feed extra calcium with a negative dietary cation-anion difference (DCAD) diet with Animate?

Research has demonstrated that feeding high levels of dietary calcium (> 180 g per head per day) result in greater amounts of available calcium (Amundson et al., 2018. J. Anim. Sci. 96:5010; Glosson et al., 2020. J. Dairy Sci. 103:7039), and greater pregnancy rates at first timed AI (Ryan et al., 2020. Theiogen. 142:338) compared to a similar DCAD diet with low dietary calcium.



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